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ESMO 2025 | RNAseq-based classification for real-world metastatic kidney cancer care

Scott Haake, MD, PhD, Vanderbilt University Medical Center, Nashville, TN, discusses the potential of RNAseq-based classification in treating metastatic kidney cancer, highlighting its feasibility and translatability to clinical practices beyond the research field. The technology enables rapid tumor biopsy, sequencing, and cluster assignment, with a timeline of approximately three weeks from consent to cluster assignments, making it compatible with real-world patient treatment. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

I really think this is a viable tool that we can use going forward. You know, we were able to metastasize, excuse me, biopsy tumors, sequence the data, assign cluster assignments, and treat patients. And our time from consent to cluster assignments by the end of the trial was maybe three weeks. And so that’s a timeline that I think is compatible with treating real world patients who have metastatic kidney cancer...

I really think this is a viable tool that we can use going forward. You know, we were able to metastasize, excuse me, biopsy tumors, sequence the data, assign cluster assignments, and treat patients. And our time from consent to cluster assignments by the end of the trial was maybe three weeks. And so that’s a timeline that I think is compatible with treating real world patients who have metastatic kidney cancer. And so I think this technology is feasible and doable and translatable to all sorts of clinical practices, not just something for the research field.

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