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ESMO 2025 | How can RNA sequencing individualize treatment selection in kidney cancer?

Scott Haake, MD, PhD, Vanderbilt University Medical Center, Nashville, TN, discusses the accessibility of RNA sequencing technology in kidney cancer. The main challenge lies in validating the data with a larger cohort, and they are exploring various ways to achieve this. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

So, you know, RNA sequencing is a mature technology. It’s readily accessible. For our trial, we use Tempus, which is a commercially available genomics company, which a lot of practices use across the country. And so it’s not an issue of technology development. If anything, it would be nice to be able to validate this data with a larger cohort. And so we’re talking to people and investigating multiple creative ways of getting that done...

So, you know, RNA sequencing is a mature technology. It’s readily accessible. For our trial, we use Tempus, which is a commercially available genomics company, which a lot of practices use across the country. And so it’s not an issue of technology development. If anything, it would be nice to be able to validate this data with a larger cohort. And so we’re talking to people and investigating multiple creative ways of getting that done. But the technology is there. The infrastructure is there. So I think we’re nearer to this than we are to almost, you know, to a lot of different biomarkers.

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