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ASCO GI 2026 | Associations of 9p21 deletions on chemo outcomes in pancreatic ductal adenocarcinoma

Jeremy Kratz, MD, University of Wisconsin Carbone Cancer Center, Madison, WI, presents findings of a study evaluating comprehensive genomic profiling in pancreatic cancer, focusing on CDKN2A/B and MTAP loss (9p21 loci deletion). Emerging PRMT5 inhibitors show promise in early-phase studies. Moving targeted therapies to localized/neoadjuvant settings could improve cure rates by optimizing upfront chemotherapy and potentiating surgical benefits. Biomarkers enable personalized therapy in advanced pancreatic cancer. This interview took place at the 2026 American Society of Clinical Oncology Gastrointestinal Cancers Symposium in San Francisco, CA.

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