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GU Cancers 2026 | ARTO: long-term OS of SBRT and abiraterone in oligometastatic prostate cancer

Giulio Francolini, MD, University of Florence, Florence, Italy, discusses long-term overall survival (OS) results from the Phase II ARTO trial (NCT03449719) of stereotactic body radiation therapy (SBRT) with abiraterone acetate and androgen deprivation therapy versus systemic treatment alone in oligometastatic castrate-resistant prostate cancer. The updated analysis demonstrated significant overall survival and prostate cancer-specific survival benefits favoring the combination approach, with no new safety concerns. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

This is a very nice data about a randomized phase 2 trial. The original study was published in 2023, showing a significant benefit for radiological progression-free survival in oligometastatic-resistant prostate cancer patients treated with SBRT plus abiraterone treatment. And this confirmed that after five years of follow-up there is a significant overall survival benefit in these patients when treated with SBRT if compared to abiraterone alone and this is the first time that a randomized trial showed this kind of benefit in this particular population...

This is a very nice data about a randomized phase 2 trial. The original study was published in 2023, showing a significant benefit for radiological progression-free survival in oligometastatic-resistant prostate cancer patients treated with SBRT plus abiraterone treatment. And this confirmed that after five years of follow-up there is a significant overall survival benefit in these patients when treated with SBRT if compared to abiraterone alone and this is the first time that a randomized trial showed this kind of benefit in this particular population.

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