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GU Cancers 2026 | PERSIAN: predictive features of complete biochemical response in prostate cancer

Giulio Francolini, MD, University of Florence, Florence, Italy, comments on predictive features of complete biochemical response from the PERSIAN trial (NCT03449719), which evaluated apalutamide and stereotactic body radiation therapy (SBRT) for low-burden metastatic hormone-sensitive prostate cancer. The analysis demonstrated a high rate of complete biochemical response, particularly in patients with fewer than three metastatic lesions. These findings suggest improved outcomes in oligometastatic disease compared to broader metastatic populations. This interview took place at the 2026 ASCO GU Cancers Symposium in San Francisco, CA.

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Transcript

It’s very interesting to see that this particular population of oligometastatic hormone-sensitive prostate cancer had a very high grade of complete biochemical response, especially if compared to the low-burden population presented in the pivotal trial in this particular kind of patients, because we saw a 92% of patients reaching a complete biochemical response rate, when actually in clinical practice a low-burden patient would have a 60% rate of complete biochemical response, so this is really interesting because it means that an oligometastatic patient, despite the number of lesions up to five, is quite different from a low-burden disease...

It’s very interesting to see that this particular population of oligometastatic hormone-sensitive prostate cancer had a very high grade of complete biochemical response, especially if compared to the low-burden population presented in the pivotal trial in this particular kind of patients, because we saw a 92% of patients reaching a complete biochemical response rate, when actually in clinical practice a low-burden patient would have a 60% rate of complete biochemical response, so this is really interesting because it means that an oligometastatic patient, despite the number of lesions up to five, is quite different from a low-burden disease.

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