Actually I think surgery will stay absolutely central in that and I think there’ll be expanded numbers of patients needing surgery. The surgery will change, it’ll be more complex. These patients do face the impact of what has happened inside their chest with the medications that they’ve been given, the treatments they’ve been given. So quite often we’ll find that nodal disease will have involuted onto the pulmonary arteries, which can be more difficult to dissect off...
Actually I think surgery will stay absolutely central in that and I think there’ll be expanded numbers of patients needing surgery. The surgery will change, it’ll be more complex. These patients do face the impact of what has happened inside their chest with the medications that they’ve been given, the treatments they’ve been given. So quite often we’ll find that nodal disease will have involuted onto the pulmonary arteries, which can be more difficult to dissect off. But having said that, I still think the majority of those cases will still be done minimally invasively. And I think patient outcomes, certainly we’re seeing that surgeons are learning how to deal with that situation very well. And it appears that there’s a low complication rate with preserved outcomes. So I think it will stay very central. Something else I think we need to consider is that currently people go down a perioperative chemo-immunotherapy plus surgery pathway if they are initially thought to be resectable. And I think that what we think of as resectable has to change. And I think that we will increasingly be offering anybody who’s got just locoregional, so not metastatic disease, chemo-immunotherapy and then assessing their response and then deciding whether or not they are resectable or whether they need to go down a radiotherapy pathway.
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