Educational content on VJOncology is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ESTRO 2026 | Biology-driven approaches to safer re-irradiation strategies

Laure Marignol, PhD, Trinity College Dublin, Dublin, Ireland, discusses the challenges of determining the safety of re-irradiation, highlighting that current methods are often insufficient and that patient outcomes can vary significantly despite similar treatment protocols. The underlying biology of the disease plays a crucial role in determining the success of re-irradiation and a deeper understanding of this biology is necessary to provide optimal care for patients. This interview took place at the European Society for Radiotherapy and Oncology 2026 Congress in Stockholm, Sweden.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.

Transcript

Yeah, so it was a very exciting debate. And I suppose I start the argument by saying that choosing whether it’s safe to re-irradiate is a really difficult question and one that we currently don’t always have an answer for. So what we do use is an idea of what dose a patient has received the first time, how long it’s been since the first year of radiation, what other treatment has been received, those kind of treatment-related questions...

Yeah, so it was a very exciting debate. And I suppose I start the argument by saying that choosing whether it’s safe to re-irradiate is a really difficult question and one that we currently don’t always have an answer for. So what we do use is an idea of what dose a patient has received the first time, how long it’s been since the first year of radiation, what other treatment has been received, those kind of treatment-related questions. But the reality is that even though we may have two patients treated the exact same way with the exact same dose, the outcomes could be very different. So my argument in the debate is that what’s underlying is really biology and until we understand the biology and take it into account, it’s going to be very difficult to serve the patients the best way.

This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.

Read more...