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ASCO 2026 | GALAXY: ctDNA dynamics and adjuvant chemotherapy in colorectal cancer
Erika Ruiz-Garcia, MD, Instituto Nacional de Cancerologia, Mexico City, Mexico, comments on findings from the GALAXY study (UMIN00039205), which analyzed circulating tumor DNA (ctDNA) dynamics at two post-surgical timepoints to identify patients with resected stage I–IV colorectal cancer (CRC) who may benefit from adjuvant chemotherapy. The results support ctDNA dynamics as a tool for treatment decision-making in this setting. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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Transcript
That’s a very nice study from the Japanese community, but it’s an observational study. So that means that the results cannot be applied instantly to the community. But we have to say that they want to check how the ctDNA works in the prognostic and predictive way. So they find out the data that they have is that supports that ctDNA is a good biomarker in the prognostic way, but not in the predictive way...
That’s a very nice study from the Japanese community, but it’s an observational study. So that means that the results cannot be applied instantly to the community. But we have to say that they want to check how the ctDNA works in the prognostic and predictive way. So they find out the data that they have is that supports that ctDNA is a good biomarker in the prognostic way, but not in the predictive way. So it needs more trials to figure out how can ctDNA help us to escalate or deescalate a treatment.
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