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ESMO 2026 | Personalized vs off-the-shelf cancer vaccines: emerging data and challenges

Han Chong Toh • 24 Oct 2026
ESMO 2026
General Antibodies Checkpoint Inhibitors Intismeran autogene Pembrolizumab
INTerpath-001

Han Chong Toh, MD, National Cancer Centre Singapore, Singapore, describes the promising future of cancer vaccines, highlighting the upcoming session on personalized cancer vaccines and the presentation of the INTerpath-001 study (NCT05933577) on an mRNA neoantigen vaccine plus pembrolizumab in melanoma. The discussion focuses on the direction of cancer vaccines, including personalized versus off-the-shelf options, manufacturing issues, and ongoing randomized trials. This interview took place at the European Society for Medical Oncology (ESMO) 2026 Congress in Madrid, Spain.

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