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ESSO 45 | Survival outcomes in total vs selective peritonectomy in ovarian cancer

Zeeba Usofi, MBBS, MS, NB, MRCS (Edinburgh), Basavatarakam Indo American Cancer Hospital & Research Institute, Telangana, India, discusses interim survival data comparing total peritonectomy with selective peritonectomy in a retrospective cohort of patients with ovarian cancer, demonstrating a superior platinum-free interval with the total peritonectomy approach despite increased operative time and blood loss. These immediate postoperative complications can be managed effectively with adequate critical care support and may represent an acceptable trade-off when considering longer-term survival benefits. This interview took place at the 2026 European Society of Surgical Oncology (ESSO) Annual Meeting in Madrid, Spain.

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Transcript

We do not have the actual survival results as of now but the interim survival results suggest that at least the platinum-free interval in patients undergoing total peritonectomy is far superior compared to those undergoing selective peritonectomy in our cohort of retrospective patients. Given that it is a bigger operation and we are spending significantly longer time and there’s significantly more blood loss during these surgeries but it is circumvented if you have a good critical care team which takes care of these problems in the immediate post-operative period...

We do not have the actual survival results as of now but the interim survival results suggest that at least the platinum-free interval in patients undergoing total peritonectomy is far superior compared to those undergoing selective peritonectomy in our cohort of retrospective patients. Given that it is a bigger operation and we are spending significantly longer time and there’s significantly more blood loss during these surgeries but it is circumvented if you have a good critical care team which takes care of these problems in the immediate post-operative period. And as I mentioned, that the platinum-free survival and maybe the overall survival later will suggest that these immediate post-operative complications are a good trade-off when we look at the bigger picture. we cannot actually run a randomized controlled trial because there comes a problem of the ethics because it’s not a standard of care. But we do have a prospective non-randomized multinational study called the Torpedo 2 study which we are a part of wherein centers who are performing total peritonectomy are comparing the results with centers who are performing selective peritonectomy and I think in the next decade we will know the actual results.

 

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