Pia Kvistborg, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands, discusses ORF1ab, a polyprotein of SARS-CoV-2, and its role in encoding an immunodominant epitope restricted by HLA-A*01:01. Data from her lab suggests that part of the ORF1ab encodes multiple CD8 T cell antigens, including one epitope which is immunodominant. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).