Heinz-Josef Lenz, MD, FACP, University of Southern California, Los Angeles, CA, provides a summary of key data presented at the American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium including the influx of biomarker-driven research as well as discussions on the role of digital pathology and radiomics. The potential of CAR T-cell therapies in colorectal cancer is also discussed by Prof. Lenz. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).