Umberto Ricardi, MD, University of Turin, Turin, Italy, discusses the management of patients with lung cancer who have brain metastases and the importance of presision medicine in treating these patients. Prof. Ricardi discusses the need to stratify patients based on prognostic factors, the need to identify biomarkers, and the use of focal radiotherapies to optimize treatment of patients with lung cancer and brain metastases. This video was recorded at the virtual European Lung Cancer Congress (ELCC) 2021.