Lisa Salvatore, MD, MS, University and Hospital Trust of Verona, Verona, Italy, discusses the findings of a Phase II study of preoperative chemoradiotherapy plus avelumab in patients with locally advanced rectal cancer. The results of the AVANA study highlight that preoperative chemoradiotherapy (chemo-RT) plus avelumab demonstrates promising activity and a feasible safety profile. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.