Following an exciting day at the ESMO 2022 meeting in Paris, France, leading gastrointestinal cancer experts get together to share their highlights. Join Geoffrey Ku and Sam Klempner as they dissect key updates in upper GI cancer. Topics covered include updates from DESTINYGastric-02 (NCT04014075) and MOONLIGHT (NCT03647969), as well as discussions on the optimal use of immunotherapy for patients with upper GI cancers. We also hear about research into potential novel biomarkers that could help with overcoming the immunosuppressive tumor microenvironment.