In this week’s VJOncology podcast, we had the opportunity to attend the 2026 ESMO Congress in Madrid, Spain, where we explored the latest advances in oncology. Join Georgina Long of the University of Sydney, Sydney, Australia, Tamim Niazi of McGill University, Montreal, Canada, James Harding of Memorial Sloan Kettering Cancer Center, New York, NY, Brian Slomovitz, Mount Sinai Comprehensive Cancer Center, Miami, FL, and Valentina Boni of University Hospital Quirónsalud, Madrid, Spain, as they discuss emerging treatment strategies and clinical trial findings, including INTerpath-001 in melanoma, DASL-HiCaP in prostate cancer, HARMONi-GI1 in biliary tract cancer, KEYNOTE-C93 in endometrial cancer, and novel therapeutics such as pumitamig and emerging PD-1-targeted bispecific and bifunctional agents in other solid tumors.