The International Workshop on CAR-T (iwCAR-T) 2022 featured many updates on the development of CAR-T therapies for the treatment of solid tumors. In this podcast, we hear from Jose Conejo-Garcia of Moffitt Cancer Center, Tampa, FL, and Jennifer Specht of Fred Hutchinson Cancer Research Center and the University of Washington, in Seattle, WA, as they discuss the latest CAR-T updates in breast cancer and ovarian cancer.