In this week’s VJOncology podcast, we explore the latest advances in skin cancer from ASCO 2025, with a focus on melanoma and emerging cellular therapies. Join Alexandra Haugh of Massachusetts General Hospital Cancer Center, Boston, MA, Kalijn Bol of Radboud University Medical Center, Nijmegen, Netherlands, Allison Betof Warner of Stanford University, Stanford, CA, Omid Hamid of The Angeles Clinic and Research Institute, Los Angeles, CA, and Peter Forsyth of Moffitt Cancer Center, Tampa, FL, as they discuss real-world outcomes with lifileucel, treatment sequencing in BRAF-mutated melanoma, emerging cellular therapies and vaccines, and preclinical approaches to CAR T-cell therapy for leptomeningeal disease.