In this week’s podcast, we take you through the latest episodes of the VJOncoAlert Journal Club—a collaborative series from VJOncology and OncoAlert that brings together leading oncology experts to discuss the most impactful and practice-changing research in the field.

We are joined by Misty Shields, MD, PhD, from the Indiana University Simon Comprehensive Cancer Center in Indianapolis, IN, who discusses the latest updates in small cell lung cancer. Thomas Powles, MBBS, MRCP, MD, of Barts Cancer Institute in London, UK, and Brian Rini, MD, FASCO, of Vanderbilt-Ingram Cancer Center in Nashville, TN, comment on the health-related quality of life (HRQoL) results from the LITESPARK-005 trial (NCT04195750) in advanced renal cell carcinoma (RCC). Berend J van der Wilk, MD, PhD, from Erasmus MC Cancer Institute in Rotterdam, Netherlands, discusses the SANO trial—a multicenter, non-inferiority, stepped wedge cluster randomized trial investigating active surveillance versus standard resection following neoadjuvant chemoradiotherapy for locally advanced esophageal cancer. Lastly, Luca Arecco, MD, from the University of Genova in Genova, Italy, comments on the prognostic implications of risk definitions from the monarchE (NCT03155997) and NATALEE (NCT03701334) trials.