Sheila Rajagopal, MD, The University of Chicago, Chicago, IL, talks on the impact that genomic tools have had on the management of breast cancer over the last 30 years. Genomic tools have been used to characterize risk which allows the use of preventative measures. Genomic platforms have also set the stage for the development of targeted therapies such as PARP inhibitors, and have facilitated a personalized approach to therapy. This interview took place at the virtual American Association for Cancer Research (AACR) Annual Meeting 2021.