Karen Mustian, PhD, MPH, ACSM of the University of Rochester Medical Center, Rochester, New York, NY, discusses advantages of using yoga as part of an exercise routine. Dr Mustian’s clinical trial showed yoga’s efficacy in improving sleep quality, insomnia, fatigue, and quality of life. In addition, Dr Mustian’s studies showed an improvement in regulation of patients’ circadian rhythm. Disruption in circardian rhythm is associated with disruptions in immune responses and inflammation, as well as sleep. Yoga helps to regulate the cancer survivor’s circadian rhythm, leading to improvements in sleep quality, insomnia, and fatigue. Recorded at the Multinational Association of Supportive Care in Cancer (MASCC) and International Society of Ocular Oncology (ISOO) 2016 Annual Meeting on Supportive Care in Cancer held in Adelaide, Australia.