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BTOG 2023 | SYSTEMS-2: radiotherapy in mesothelioma

Riyaz Shah, BSc(Hons), MBBS, FRCP, PhD, Kent Oncology Centre, Maidstone, UK, provides insights into the SYSTEMS-2 trial which suggests that mesothelioma may be more radiosensitive than generally thought. The study aimed to determine whether administering higher doses of radiotherapy better controls pain in patients with malignant pleural mesothelioma (MPM). While the results were not statistically significant, when considering the secondary endpoint of OS, an interesting survival difference was noted. This immature data suggests that higher-dose radiotherapy treatment could affect survival outcomes. This new research avenue feeds nicely into upcoming trials such as the HIT-Meso study (NCT05655078). This interview took place at the British Thoracic Oncology Group (BTOG) Annual Conference 2023 in Belfast, UK.

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