The omission of anthracyclines was a highly debated topic at the St. Gallen Consensus Session 2021. Lisa Carey, MD, FASCO, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC, talks on the necessity of anthracyclines in triple negative breast cancer (TNBC). While the toxicity profile of these drugs makes their omission appealing, evidence continues to support their use in TNBC. This interview took place during the 17th St. Gallen International Breast Cancer Conference.