Alastair Greystoke, MBChB, MSc, PhD, MRCP, Northern Institute for Cancer Research, Newcastle University, Newcastle, UK, gives an overview of future challenges in lung cancer treatment, including the increasing individualization and specialization of lung cancer treatment, the changing demographic of patients who have lung cancer, and novel therapies. This interview took place during the 19th British Thoracic Oncology Group (BTOG) Annual Conference 2021.