ESMO 2023 | The use of ctDNA in identifying post-surgical CRC residual disease status

Yoshiaki Nakamura, MD, PhD, National Cancer Center Hospital East, Kashiwa, Japan, explains the results of the GALAXY arm of the ongoing CIRCULATE-Japan trial (UMIN000039205) considering circulating tumor DNA (ctDNA) as a useful indicator in colorectal cancer (CRC). Disease-free survival (DFS) positively correlated with ctDNA levels and when stratifying molecular residual disease (MRD) groups using ctDNA, patients who were MRD-positive significantly benefitted from adjuvant chemotherapy (ACT), whereas patients who were MRD-negative did not. This presents ctDNA as a beneficial indicator to identify patients who are likely to benefit from post-surgical ACT. This interview took place at the European Society for Medical Oncology (ESMO) 2023 Congress in Madrid, Spain.

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