Sunandana Chandra, MD, MS, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, reviews data reported from the PRADO study (NCT02977052). This phase II study investigated personalized response-driven surgery and adjuvant therapy following neoadjuvant ipilimumab and nivolumab in patients with resectable stage III melanoma. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).