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ESMO 2022 | Final OS results from PAOLA-1 evaluating 1L maintenance olaparib plus bevacizumab

Nicoletta Colombo, MD, PhD, Istituto Europeo di Oncologia, Milan, Italy, discusses the final overall survival (OS) results from the Phase III PAOLA-1/ENGOT-ov25 trial (NCT02477644) evaluating maintenance olaparib plus bevacizumab in patients with newly diagnosed advanced ovarian cancer. The combination of olaparib and bevacizumab provided a clinically meaningful improvement in overall survival for first-line homologous recombination deficient patients with and without a BRCA mutation, confirming olaparib and bevacizumab as a standard of care in this setting. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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