Hielke-Martijn De Vries, MD, Netherlands Cancer Institute, Amsterdam, Netherlands, talks on the findings of a retrospective analysis investigating the number of positive inguinal lymph node dissections (ILNDs) after a positive dynamic sentinel node biopsy (DSNB). Data from 345 patients with intermediate to high-risk penile cancer with at least one tumor-positive node at DSNB was analyzed. Overall, the study reported that in patients with cN0 penile cancer with a tumor-positive DSNB, additional tumor-positive nodes at ILND were found in 16% of cases. Positive nodes at ILND were associated with having a higher number of positive nodes, a lower number of negative nodes, and large intranodal metastasis size at DSNB. Dr De Vries comments on the implications of the findings of this study for clinical practice. This interview took place at the virtual European Association of Urology (EAU) Virtual Meeting 2021.