IASLC TTLC 2024 | The role of DLL3-directed agents in treating SCLC

Ticiana Leal, MD, Winship Cancer Institute, Atlanta, GA, discusses the use of DLL3-directed agents for treating small cell lung cancer (SCLC). DLL3 is expressed in up to 85% of SCLC and extra-pulmonary SCLC cases. Current studies, in different phases of development, are using T-cell engagers to target DLL3. The Phase I DeLLphi-300 study (NCT03319940) evaluated the use of tarlatamab on heavily patients with pre-treated SCLC. The results demonstrated a promising response rate and overall survival, as well as a strong safety profile with low rates of discontinuation due to adverse events, most of which were grade I and II reversible cytokine response syndrome (CRS). The Phase II DeLLphi-301 study (NCT05060016) showed good responses at a dosage of 10 milligrams. This interview took place at 2024 Targeted Therapies of Lung Cancer Meeting (TTLC 2024) in Santa Monica, CA.

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