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IASLC TTLC 2024 | Overview and advances in tumor treatment fields (TTFields)

Ticiana Leal, MD, Winship Cancer Institute, Atlanta, GA, outlines what tumor treatment fields (TTFields) treatment entails and its potential advancements. TTFields are electric fields tuned to a frequency that interferes with mitosis, thereby disrupting the rapid cell division in cancers and tumors, as well as stimulating an enhanced immune response. TTFields has been approved for glioblastomas and malignant pleural mesotheliomas and its efficacy against non-small cell lung cancer (NSCLC) was assessed in the Phase III LUNAR study (NCT02973789), where patients received the standard of care (an immune checkpoint inhibitor or docetaxel) with or without TTFields. TTFields combined therapy demonstrated improved overall survival (OS), particularly in combination with immune checkpoint inhibitors. This interview took place at 2024 Targeted Therapies of Lung Cancer Meeting (TTLC 2024) in Santa Monica, CA.

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