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ASCO GI 2023 | Biomarkers of treatment response in patients with MMR-proficient CRC

Richard Kim, MD, Moffitt Cancer Center, Tampa, FL, discusses findings from a biomarker analysis of patients with metastatic mismatch repair proficient (pMMR) colorectal cancer (CRC) receiving regorafenib and nivolumab. Tissue samples were subjected to the Xerna TME Panel, and potential predicative biomarkers were assessed. Whilst KRAS and PD-L1 did not determine treatment outcomes, low Treg in the tumor microenvironment was associated with longer progression-free survival (PFS). This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Gastrointestinal Cancers (GI) Symposium in San Francisco, CA.

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