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ESMO 2022 | RINGSIDE: Phase II/III trial of AL102 for the treatment of desmoid tumors

Robin Jones, MBBS, MRCP, MD, The Royal Marsden NHS Foundation Trust, London, UK, discusses results from part A of the Phase II/III RINGSIDE (NCT04871282) investigating 3 doses of the gamma secretase inhibitor, AL102, in desmoid tumors. Phase II is open-label with safety as the primary endpoint. Phase III is a double-blind, placebo-controlled study with progression-free survival (PFS) as the primary endpoint. 30 patients with progressive desmoid tumors were enrolled into Phase II. There were no deaths or life-threatening treatment-related adverse events (TREAEs). The most common AEs were diarrhea, rash, nausea, fatigue and stomatitis. In terms of efficacy, early volume and RECIST responses were observed in all 3 dose arms at week 16. Prof. Jones also discusses further efficacy responses. This interview took place at the European Society for Medical Oncology (ESMO) 2022 Congress in Paris, France.

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