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ESMO 2025 | What role will ctDNA play in patient selection in GIST and other sarcomas?

Robin Jones, MBBS, MRCP, MD, Institute of Cancer Research, London, UK, discusses the potential of circulating tumor DNA (ctDNA) in assessing disease response and status in gastrointestinal stromal tumors (GIST). The Phase III INTRIGUE trial (NCT03673501) of ripretinib versus sunitinib in patients with KIT exon 11 and 17/18 mutations will provide valuable insights into the role of ctDNA in metastatic GIST. This interview took place at the European Society for Medical Oncology (ESMO) 2025 Congress in Berlin, Germany.

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Transcript

I think gastrointestinal stromal tumors are just really leading the way in terms of the use of ctDNA in assessing disease response and disease status. As I mentioned, the randomized trial of ripretinib versus sunitinib, a second-line therapy in patients with kit exon 11 and kit exon 17 and 18 CT DNA positive disease will be absolutely informative in terms of the role of ctDNA in metastatic GIST and will hopefully lead to further evaluation in other sarcoma subtypes...

I think gastrointestinal stromal tumors are just really leading the way in terms of the use of ctDNA in assessing disease response and disease status. As I mentioned, the randomized trial of ripretinib versus sunitinib, a second-line therapy in patients with kit exon 11 and kit exon 17 and 18 CT DNA positive disease will be absolutely informative in terms of the role of ctDNA in metastatic GIST and will hopefully lead to further evaluation in other sarcoma subtypes.

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