Christian Blank, MD, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands, gives an overview of the use of ipilimumab plus nivolumab for the treatment of stage III melanoma in the neoadjuvant setting, highlighting findings from a pooled analysis of six trials. He describes the limitations of targeted therapy and outlines the benefits of nivolumab and ipilimumab combinations in comparison to monotherapy approaches. This interview took place during the 10th World Congress of Melanoma in conjunction with the 17th EADO Congress Interactive Virtual Meeting.