Christian Blank, MD, PhD, Netherlands Cancer Institute, Amsterdam, The Netherlands, provides an update on the Phase Ib OpACIN (NCT02437279) of neoadjuvant ipilimumab plus nivolumab (IPI + NIVO) in patients with stage III melanoma. Following a 4-year median follow-up, no patients with a pathologic response had relapsed and only early relapses were seen in non-responders. Similar results are observed in the subsequent Phase II OpACIN-neo study (NCT02977052), which evaluated three different dosing schedules of neoadjuvant IPI + NIVO in 86 patients with stage III melanoma. This interview took place during the 10th World Congress of Melanoma in conjunction with the 17th EADO Congress Interactive Virtual Meeting.