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ASCO 2026 | How will daraxonrasib change the treatment landscape of pancreatic cancer?

Zev Wainberg, MD, University of California, Los Angeles, CA, discusses the potential approval of daraxonrasib and its implications for the field of pancreatic cancer, highlighting the need to test RAS inhibitors at every stage of the disease. Ongoing trials are additionally exploring combination therapies with various KRAS inhibitors, which may lead to improved outcomes for patients. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

So first, we hope daraxonrasib gets approved. That’s the target, and that hopefully will happen at least in the United States very shortly, and I suspect around the world. In terms of what that means practically, more patients will have access to the drug. More people will be able to have access to this, hopefully, this potent drug. What it means for the field, I think, beyond that, is we need to start testing RAS inhibitors at every step of the way in pancreatic cancer...

So first, we hope daraxonrasib gets approved. That’s the target, and that hopefully will happen at least in the United States very shortly, and I suspect around the world. In terms of what that means practically, more patients will have access to the drug. More people will be able to have access to this, hopefully, this potent drug. What it means for the field, I think, beyond that, is we need to start testing RAS inhibitors at every step of the way in pancreatic cancer. Early-stage disease, locally advanced disease, resectable disease, all across the board. In fact, trials are already ongoing in all those aspects with combination, not just with daraxonrasib , but also with other KRAS inhibitors, allele-specific drugs, PAN RAS, you name it. So this is the avenue that we have to take over the next few years because that’s the avenue that will, in my opinion, produce the best results.

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