Maria Fernanda Mosele, MD, Gustave Roussy, Villejuif, France, talks on the significance of HER2 expression for the activity of trastuzumab deruxtecan (T-DXd), noting on a significant difference in TDX-D distribution in tumor according to HER2 expression. This interview took place at the European Society for Medical Oncology (ESMO) Breast Cancer 2022 congress in Berlin, Germany.