John V. Reynolds, MD, St. James’s Hospital and Trinity College Dublin, Dublin, Ireland, discusses findings from the Neo-AEGIS study (NCT01726452), a Phase III neoadjuvant trial in adenocarcinoma of the esophagus and esophago-gastric junction cancer evaluating CROSS verses perioperative chemotherapy. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.