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ASCO 2023 | The case for separating G12D mutations in studying KRAS-mutant PDAC

Bach Ardalan, MD, University of Miami, Coral Gables, FL, comments on the frequency of KRAS mutations in pancreatic ductal adenocarcinoma (PDAC), which has a very high mutation rate. G12D is the most frequent KRAS variants, followed by G12V and G12R; these three mutations have different genomic profiles and survivorship rates, resulting in the need for separate cohorts in studies. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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