Brian H. Ramnaraign, MD, University of Florida College of Medicine, Gainesville, FL, discusses the rationale of an ongoing Phase II trial investigating the PARP inhibitor, niraparib, in BRCA-1 associated Protein 1 (BAP1) and other DNA damage response (DDR) pathway deficient neoplasms, including patients with cholangiocarcinoma. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).