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ASCO 2025 | Future directions in managing MSI-H gastrointestinal cancers
Anna Maria Di Giacomo, MD, University Hospital of Siena, Siena, Italy, describes recent updates in the treatment of mismatch repair deficiency (MSI-H) metastatic gastrointestinal cancer, with the possibility of curative intent. Adjuvant therapy in this setting will be important, where a significant practice change based on evidence from previous trials is possible. This interview took place during the 2025 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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Transcript
Very interesting results have been presented about the role, for example, of a combination of adjuvant therapy in MSI-H patients in gastrointestinal cancer. Also, previous trials have clearly demonstrated also in the metastatic disease that we are able probably to cure some of these patients with metastatic disease. And so the possibility to treat in an adjuvant setting, so after a radical resection, I think that is a very important effort and a very important practice change evidence...
Very interesting results have been presented about the role, for example, of a combination of adjuvant therapy in MSI-H patients in gastrointestinal cancer. Also, previous trials have clearly demonstrated also in the metastatic disease that we are able probably to cure some of these patients with metastatic disease. And so the possibility to treat in an adjuvant setting, so after a radical resection, I think that is a very important effort and a very important practice change evidence.
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