Alastair Greystoke, PhD, MBChB, PhD, MRCP, University of Newcastle & Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, discusses advances in personalized therapies for patients with lung cancer. The number of available treatments for specific mutations such as EGFR, ALK, ROS1, and MET exon 14 skipping mutant lung cancer have increased over the years. Targeted therapies for KRAS p.G12C–mutated lung cancer, as well as immunotherapies targeting PD-L1 have also meant more patients can access personalized therapies. Dr Greystoke additionally comments on need for wider adoption of liquid biopsies, which will improve detection and treatment outcomes. This interview took place at the 20th Annual British Thoracic Oncology Group (BTOG) Conference 2022.