GI Malignancies Debate 2022 | Checkpoint inhibition in hepatocellular carcinoma

Ghassan Abou-Alfa, MD, MBA, Memorial Sloan Kettering Cancer Center, New York, NY, provides an overview of immune checkpoint inhibitors (ICIs) in treating hepatocellular carcinoma. Current double therapies incorporating ICIs including durvalumab and tremelimumab as well as atezolizumab and bevacizumab have been assessed in clinical trials such as the Phase III IMbrave150 trial (NCT03434379) of the latter combination against sorafenib. Prof. Abou-Alfa additionally highlights data from a real world study which shows patients with hepatitis B are especially more likely to benefit from checkpoint inhibition. This interview took place virtually at the 2022 Great Debates & Updates in Gastrointestinal Malignancies Congress.

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