ESMO Asia 2023 | Continued use of osimertinib reduces CNS metastasis in EGFR mutant lung cancer

Molly Li, MMBS, Queen Elizabeth Hospital, Hong Kong, walks through how continued osimertinib administration alongside chemotherapy reduces progression in patients with EGFR-mutant non-small cell lung cancer (NSCLC). Central nervous system (CNS) progression is common in patients with epidermal growth factor receptor (EGFR) mutations, which are prevalent in Asia. Standard treatment for these patients who fail to respond to osimertinib is chemotherapy, although this has limited activity in the CNS. A retrospective analysis of 180 patients that suggests continuing osimertinib use alongside chemotherapy may reduce CNS progression. Results showed that CNS progression and salvage whole brain radiation rate was reduced in the chemotherapy and osimertinib cohort, despite progression-free survival being statistically insignificant. Dr Li states that these results support the conclusions drawn from the FLAURA2 trial (NCT04035486). This interview took place at the European Society for Medical Oncology (ESMO) Asia 2023 Congress in Singapore.

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