ESMO Asia 2023 | Evaluating the use of cell-based therapies in lung cancers

Molly Li, MBBS, Queen Elizabeth Hospital, Hong Kong, discusses our current status on the development of cell-based therapies for lung cancer. Dr Li explains that there is limited clinical data on the use of cellular therapies in lung cancer because of the difficulty in identifying a specific antigen target for tumor-infiltrating lymphocyte (TIL) therapy. Additionally, the immunosuppressive microenvironment present in lung cancer limits the efficacy of cellular therapies in general. Despite these challenges, a Phase I trial (NCT04035486) of a novel TIL therapy with nivolumab in patients with anti-PD-1 resistant lung cancer was shown to be promising. Thus, the lung-cancer-specific hurdles notwithstanding, cellular therapy has a promising outlook in future research. This interview took place at the European Society for Medical Oncology (ESMO) Asia 2023 Congress in Singapore.

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