Adam Schoenfeld, MD, Memorial Sloan Kettering Cancer Center, New York, NY, outlines his presentation at ELCC 2021 on mechanisms of acquired resistance against immunotherapy in patients with lung cancer. Dr Schoenfeld highlights the importance of understanding mechanisms of resistance in order to improve novel therapies and the current lack of research in this field. This video was recorded at the virtual European Lung Cancer Congress (ELCC) 2021.