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ASCO 2023 | Efficacy of sacituzumab govitecan in mUC by Trop-2 expression

Scott Tagawa, MD, MS, FACP, Weill Cornell Medical Center, New York, NY, takes us through a study which evaluated the efficacy of sacituzumab govitecan, a Trop-2-directed antibody-drug conjugate, in patients with previously treated locally advanced or metastatic urothelial carcinoma (mUC) based on Trop-2 expression in archival tumor samples. The analysis included three cohorts (C1, C2, C3) with varying response rates. Trop-2 protein was found to be highly expressed in all cohorts. The objective response rates (ORRs), progression-free survival (PFS), and overall survival (OS) were similar between patients with below or above median Trop-2 expression. These findings suggest that sacituzumab govetican activity in urothelial carcinoma may not depend on Trop-2 expression, but further research is needed to confirm these results. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.

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