Brian Van Tine, MD, PhD, Washington University School of Medicine in St.Louis, St Louis, MO, discusses key updates in the treatment and management of patients with sarcoma from the American Society of Clinical Oncology (ASCO) 2021 meeting, including the updates from the SPEARHEAD study (NCT04044768) in synovial sarcoma, updates in the use of PARP inhibitors, and biomarkers of response. This interview took place at the American Society of Clinical Oncology (ASCO) 2021 Virtual Meeting.