Well, in fact, the EAU guidelines recommend radical cystectomy as the first therapy for a very high-risk non-muscle-invasive bladder cancer, but we know it might be an overtreatment in a relevant population within this group. We know that the classification by the EAU guidelines does not include patients treated with BCG, and we know that when we treat with BCG, these patients, induction plus maintenance, we have a relevant number of responders...
Well, in fact, the EAU guidelines recommend radical cystectomy as the first therapy for a very high-risk non-muscle-invasive bladder cancer, but we know it might be an overtreatment in a relevant population within this group. We know that the classification by the EAU guidelines does not include patients treated with BCG, and we know that when we treat with BCG, these patients, induction plus maintenance, we have a relevant number of responders. So, although it is stated in the guidelines as the first-line therapy for very high-risk BCG-naive, high-risk patients, very high-risk patients, we should select and individualize in this population because there are some of them, a quite large number of them, for whom it will be an overtreatment.
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