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ASCO 2026 | Decision regret in patients with kidney cancer following adjuvant therapy

Elizabeth Nally, MBBS, Barts Cancer Institute, London, UK, discusses the relationship between adjuvant therapy and decision regret in patients with kidney cancer, noting that those with long-term toxicity were most likely to experience regret. Dr Nally highlights that the severity of toxicity and disease recurrence were not associated with decision regret, with many patients expressing relief at having undergone treatment despite cancer recurrence. This interview took place during the 2026 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.

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Transcript

So we asked over 100 patients to reflect on their decision to accept adjuvant therapy a year down the line. The patients, on the whole, decision regret was fairly low, but the patients that were most likely to regret it with the highest scores were those patients that had a long-term toxicity. We looked at whether CTCAE grading was associated with decision regret, and it wasn’t...

So we asked over 100 patients to reflect on their decision to accept adjuvant therapy a year down the line. The patients, on the whole, decision regret was fairly low, but the patients that were most likely to regret it with the highest scores were those patients that had a long-term toxicity. We looked at whether CTCAE grading was associated with decision regret, and it wasn’t. And also, interestingly, disease recurrence wasn’t associated with regret. Patients would often tell me that they were glad they’d given it a go, even though their cancer had come back. So to summarize, it’s this long-term toxicity, these life-changing effects that do seem to be most associated with regret. And it really, again, highlights the importance of making sure our patients are as well-informed as possible.

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